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CDE Diabetes

CDE Exam Study Guide: Clinical Practice Guidelines Appendices (2018)

1. Diabetes Charter (Appendix 1)

Key Takeaway: The Charter defines the rights and responsibilities of people living with diabetes, healthcare providers, governments, and organizations. The central theme is dignity, respect, and equity.

  • The Vision: A country where people with diabetes live to their full potential.
  • Guiding Principles:
    • Treat people with dignity and respect.
    • Advocate for equitable access to care.
    • Enhance quality of life for patients and caregivers.

A. Rights of Canadians with Diabetes

  • Respect & Dignity: To be free from stigma and discrimination.
  • Access: Affordable/timely access to meds, devices, supplies, and healthy food regardless of income or location.
  • Care Team: Timely diagnosis and education from an interprofessional team (nurse, dietitian, pharmacist, etc.).
  • Decision Making: To be an active partner in decisions regarding their own care.
  • Accommodation:
    • Schools/Daycares: Full participation with reasonable accommodation and assistance.
    • Workplaces: Supportive environments that do not discriminate and provide reasonable accommodation.

B. Responsibilities of Canadians with Diabetes

  • Self-Management: Manage diet, exercise, and medication to the best of their ability and personal circumstances.
  • Transparency: Be honest and open with health providers to allow for suitable care plans.
  • Education: Actively seek information and support.

C. Responsibilities of Health-Care Providers

  • Partnership: Treat people with diabetes as full partners in their care.
  • Evidence-Based Care: Apply up-to-date clinical practice guidelines (CPG).
  • Early Diagnosis: Diagnose diabetes as early as possible.
  • System Navigation: Help patients navigate the healthcare system.

D. Institutional Responsibilities

  • Schools/Daycares: Must ensure staff have accurate information, provide a safe environment for self-management, and protect children from discrimination.
  • Workplaces: Must eliminate discrimination and provide accommodation.
  • Governments: Guarantee fair access to care regardless of income/location and address disparities in vulnerable populations.

2. Etiology & Classification (Appendix 2)

Key Takeaway: While Type 1 and Type 2 are most common, you must recognize “Other Specific Types” often triggered by medications or genetics.

  • Drug-Induced Diabetes: Be able to identify drugs that induce hyperglycemia:
    • Glucocorticoids (e.g., prednisone)
    • Atypical Antipsychotics (e.g., clozapine, olanzapine)
    • Statins (HMG CoA reductase inhibitors)
    • Thiazides (diuretics)
    • Calcineurin inhibitors (transplant drugs)
  • Genetic Syndromes: Commonly associated with diabetes include Down syndrome, Turner syndrome, and Klinefelter syndrome.

3. Physical Activity Prescription (Appendix 4)

Key Takeaway: “Smarter Step Count” prescription.

  • Goal: Increase baseline step count by 3,000 steps per day within 1 year.
  • Increments:
    • If baseline <5,000 steps: Add 500 steps at first visit.
    • If baseline 5,000-7,499: Add 750 steps at first visit.
    • If baseline 7,500: Add 1,000 steps at first visit.

5. Self-Monitoring of Blood Glucose (SMBG) (Appendix 5)

Key Takeaway: Frequency of testing depends on the treatment regimen and glycemic stability.

  • Basal-Bolus (MDI) or Pump: Test 4 times daily (before meals and bedtime).
  • Oral Agents / Lifestyle only: If meeting targets, frequent testing is not usually required.
  • Newly Diagnosed (<6 mos): Test 1 time/day at different times to learn how lifestyle affects BG.
  • Safety Occupations: As required by employer/driving guidelines.

6. Insulin Pharmacokinetics (Appendix 6)

Key Takeaway: You must know the Onset, Peak, and Duration to troubleshoot hypoglycemia or hyperglycemia patterns.

Insulin TypeExamplesOnsetPeakDuration

Rapid-
Acting

Aspart, Lispro,
Glulisine
10–15 min1–2 h

3–5 h

 

 

Short-
Acting
Regular
(Toronto)
30 min2–3 h

6.5 h

 

 

IntermediateNPH (Cloudy)1–3 h5–8 h

Up to 18 h

 

 

Long-
Acting
Glargine U-100, Detemir90 minNone

Up to 24 h

 

 

Ultra-LongDegludec,
Glargine U-300
90 minNone

>30 h

 

 

7. Sick Day Management: "SADMANS" (Appendix 8)

Key Takeaway: When a patient is ill, dehydrated, or has acute renal decline, certain medications must be PAUSED to prevent acute kidney injury (AKI) or adverse effects.

Instructions: Stop the following meds if unable to maintain hydration; restart when well.

  • SSulfonylureas (risk of hypoglycemia)
  • AACE Inhibitors (risk of renal decline)
  • DDiuretics / Direct Renin Inhibitors (risk of volume depletion)
  • MMetformin (risk of lactic acidosis/reduced clearance)
  • AAngiotensin Receptor Blockers (ARBs) (risk of renal decline)
  • NNon-steroidal Anti-inflammatory Drugs (NSAIDs) (risk of renal decline)
  • SSGLT2 Inhibitors (risk of DKA/volume depletion)

Exam Tip: Remember that insulin should not inherently be stopped during sick days; often doses need adjustment (usually increasing) due to stress hyperglycemia, but the “SADMANS” list refers specifically to non-insulin meds that pose safety risks during dehydration.

8. Insulin Initiation & Titration in T2D (Appendix 9)

Key Takeaway: The standard approach for starting insulin in Type 2 Diabetes involves safety first (avoiding hypo) and gradual titration.

  • Starting Basal Insulin:
    • Start: 10 units at bedtime.
    • Titrate: Increase by 1 unit per day until fasting glucose target (4.0–7.0 mmol/L) is reached.
    • Exception: Degludec is titrated every 3–4 days (2 units) or once weekly (4 units) due to longer half-life.
  • Safety Rule: Do not increase dose if the patient has >2 hypo episodes (<4.0 mmol/L) in a week or any nocturnal hypoglycemia.
  • Adding Bolus (Basal Plus): Start 2–4 units at one meal (usually largest). Titrate by 1 unit daily to target 2hr post-meal 8.0 mmol/L .

9. Driving Guidelines (Appendix 10)

Key Takeaway: Assessment for fitness to drive focuses on hypoglycemia awareness and severity.

  • Commercial Drivers: Disqualified if they have any episodes of severe hypoglycemia during waking hours in the past 12 months .
  • Private Drivers: Assessment focuses on severe hypoglycemia in the past 6 months .
  • Monitoring Rule: Drivers on insulin/secretagogues must monitor at least every 4 hours while driving.
  • Supplies: Must have monitoring equipment and rapid carbs within reach in the vehicle.

10. Foot Care & Neuropathy Screening (Appendices 11, 12, 13)

Key Takeaway: Screening must be done annually using a 10g Monofilament or 128 Hz Tuning fork to assess risk of ulceration.

A. 10g Semmes-Weinstein Monofilament Test

  • Technique: Apply perpendicular to skin until it buckles for ~1 second.
  • Sites: Dorsum of great toe (screening) or plantar sites (comprehensive).
  • Scoring (Screening):
    • Test 8 stimuli (4 per foot).
    • Score < 3/8 correct = Likely Neuropathy.
    • Protective sensation is absent if 2 out of 3 applications at a single site are incorrect.

B. 128 Hz Tuning Fork (On-Off Method)

  • Apply to the bony prominence of the great toe.

  • Patient must identify when vibration is felt and when it stops.

C. Foot Care Checklist

  • DO: Check feet daily, use mirror, trim nails straight across, buy shoes in late afternoon (feet swell).
  • DO NOT: Soak feet, use hot water bottles, walk barefoot, use over-the-counter corn/wart removers.

References:

Appendix 1: Diabetes Canada Diabetes Charter. Canadian Journal of Diabetes. 2018;42:S307. doi:10.1016/j.jcjd.2017.11.001
Appendix 2: Etiologic Classification of Diabetes Mellitus. Canadian Journal of Diabetes. 2018;42:S308. doi:10.1016/j.jcjd.2017.10.041
Appendix 3: Examples of Insulin Initiation and Titration Regimens in People with Type 2 Diabetes. Canadian Journal of Diabetes. 2013;37, Supplement 1:S200-S201. doi:10.1016/j.jcjd.2013.02.041
Appendix 4: Smarter Step Count Prescription. Canadian Journal of Diabetes. 2018;42:S311. doi:10.1016/j.jcjd.2017.12.005
Appendix 5: Self-Monitoring of Blood Glucose (SMBG) Recommendation Tool for Health-Care Providers. Canadian Journal of Diabetes. 2018;42:S312-S313. doi:10.1016/j.jcjd.2017.10.043
Appendix 6: Therapeutic Considerations for Renal Impairment. Canadian Journal of Diabetes. 2013;37, Supplement 1:S207-S208. doi:10.1016/j.jcjd.2013.02.044
Diabetes Canada. Appendix 6: Types of Insulin. Canadian Journal of Diabetes. 2018;42:S314. doi:10.1016/j.jcjd.2017.12.006
Appendix 8: Sick-Day Medication List. Canadian Journal of Diabetes. 2018;42:S316. doi:10.1016/j.jcjd.2017.10.045
Diabetes Canada. Appendix 9: Examples of Insulin Initiation and Titration Regimens in People With Type 2 Diabetes. Accessed April 11, 2025. https://guidelines.diabetes.ca/appendices/appendix9
Appendix 10: Sample Diabetes and Driving Assessment Form. Canadian Journal of Diabetes. 2018;42:S319. doi:10.1016/j.jcjd.2017.10.050
Appendix 11A: Rapid Screening for Diabetic Neuropathy Using the 10 g Semmes-Weinstein Monofilament. Canadian Journal of Diabetes. 2018;42:S320. doi:10.1016/j.jcjd.2017.10.046
Appendix 11B: Rapid Screening for Diabetic Neuropathy Using the 128 Hz Vibration Tuning Fork (the “On-Off” Method). Canadian Journal of Diabetes. 2018;42:S321. doi:10.1016/j.jcjd.2017.10.054
Appendix 12: Monofilament Testing in the Diabetic Foot. Canadian Journal of Diabetes. 2018;42:S322. doi:10.1016/j.jcjd.2017.10.047
Appendix 13: Diabetes and Foot Care: A Checklist. Canadian Journal of Diabetes. 2018;42:S323. doi:10.1016/j.jcjd.2017.10.048
Appendix 14: Diabetic Foot Ulcers—Essentials of Management. Canadian Journal of Diabetes. 2018;42:S324. doi:10.1016/j.jcjd.2017.10.049
Appendix 15: Glycated Hemoglobin Conversion Chart. Canadian Journal of Diabetes. 2018;42:S325. doi:10.1016/j.jcjd.2017.10.051