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CDE Diabetes

Practice Exam: Screening for the Presence of Cardiovascular Disease (Chapter 24)

Individuals with diabetes are at a significantly higher risk of developing cardiovascular disease (CVD) and often present with “silent” ischemia, meaning they may suffer a myocardial infarction without experiencing typical chest pain. The 2018 Clinical Practice Guidelines provide specific criteria for when—and how—to screen for coronary artery disease (CAD) to ensure resources are used effectively.

This practice exam tests your ability to identify which patients require routine screening (e.g., resting ECG) versus those who require further investigation (e.g., stress testing) based on their symptom profile and risk factors.

Key Concepts Covered in This Exam:

  • The “Silent” Threat: Understanding that a large proportion of people with diabetes will have no symptoms prior to a fatal or nonfatal myocardial infarction.

  • Resting ECG Guidelines: Identifying who should receive a baseline resting ECG and how often it should be repeated (e.g., every 3 to 5 years) for patients with specific risk factors.

  • Indications for Stress Testing: Recognizing that routine stress testing is not recommended for asymptomatic individuals, but is indicated for those with typical or atypical cardiac symptoms, or associated diseases like peripheral artery disease (PAD).

  • Assessment of Prognosis: Knowing when exercise stress testing is useful for assessing prognosis in high-risk individuals versus when functional imaging might be preferred.

  • Referral Criteria: Determining when a patient should be referred to a cardiac specialist for further evaluation.

1. Approximately what proportion of myocardial infarctions in people with diabetes occur without recognized or typical symptoms (silent MIs)?

2. The age-adjusted relative risk for CVD in type 1 diabetes is how many times that of the general population?

3. Which of the following CVD risk factors qualifies as an indication for resting ECG screening according to the guidelines?

4. How often should a resting ECG be repeated in individuals with diabetes who meet screening criteria?

5. What coronary artery calcium (CAC) score threshold is used as an indication for exercise ECG stress testing?

6. What percentage of older asymptomatic individuals with type 2 diabetes and microalbuminuria have silent MI?

7. What is the strongest and most consistent prognostic marker identified during exercise ECG stress testing?

8. Which of the following resting ECG abnormalities limits the diagnostic accuracy of an exercise ECG stress test?

9. A 55-year-old woman with type 2 diabetes has severe peripheral neuropathy and foot pathology that prevents her from walking on a treadmill. She requires cardiac stress testing. What type of stress test is appropriate for this patient?

10. At what exercise capacity threshold should individuals with diabetes demonstrating ischemia be referred to a cardiac specialist?

11. In what percentage of individuals with diabetes will typical chest pain or discomfort be absent?

12. Case 9: A 42-year-old woman with well-controlled type 2 diabetes is planning to start high-intensity interval training. According to the guidelines, should a resting ECG be performed before she begins this exercise program?

13. A 58-year-old man with type 2 diabetes undergoes exercise stress SPECT myocardial perfusion imaging and achieves 11 METs despite having significant perfusion defects. What is the expected annualized cardiac event rate for this patient?

14. What is the most predictive clinical observation for coronary artery disease in persons with or without diabetes?

15. What percentage of people with diabetes will die from heart disease?

16. What is the odds ratio for ST-T abnormalities at rest as a predictor of silent ischemia in people with diabetes?

17. A 52-year-old woman with type 2 diabetes complains of unexplained dyspnea on exertion. Her resting ECG is normal and she has no baseline ST abnormalities. What is the recommended initial investigation for CAD in this patient?

18. What is the annual CAD event rate in people with diabetes and silent ischemia?

19. According to the guidelines, which of the following is an indication for exercise ECG stress testing as the initial test?

20. How do major CVD events in type 1 diabetes compare temporally to matched controls without diabetes?

21. Case 7: A 62-year-old woman with type 2 diabetes has absent dorsalis pedis and posterior tibial pulses on examination. What is the significance of absent peripheral pulses in this patient?

22. Case 8: A 35-year-old man with type 1 diabetes of 20 years duration has no cardiac symptoms. He asks about his cardiovascular risk. According to the guidelines, should a resting ECG be performed?

23. What is the approximate increased risk of peripheral arterial disease (PAD) in people with type 2 diabetes compared to the population without diabetes?

24. Case: A patient with type 2 diabetes has no coronary artery calcium (CAC score = 0) detected on CT imaging. What is the prognostic significance of no detectable CAC in people with diabetes?

25. A 45-year-old man with type 2 diabetes of 8 years duration presents for a routine visit. He has hypertension, is a current smoker, and has a BMI of 32 kg/m². He is asymptomatic. According to the guidelines, should a resting ECG be performed in this patient?

26. Case: A 45-year-old woman with type 1 diabetes is concerned about her cardiovascular risk compared to a woman without diabetes. What is the hazard ratio for major CAD events in women with type 1 diabetes compared to the general population?

27. Case: A 50-year-old man with type 2 diabetes has a history of transient ischemic attack (TIA) 6 months ago. He is currently asymptomatic for cardiac symptoms. According to the guidelines, should he undergo exercise ECG stress testing?

28. Case 3: A 60-year-old man with type 2 diabetes needs cardiac stress testing but has a left bundle branch block on his resting ECG. What type of stress test should be performed?

29. What is the sensitivity and specificity of an abnormal posterior tibial pulse for detection of PAD?

30. Case 6: A 48-year-old asymptomatic man with type 2 diabetes undergoes coronary CTA and has no evidence of coronary artery disease. What is the prognostic warranty period for this patient based on the normal coronary CTA result?