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CDE Diabetes

Practice Exam: Type 1 Diabetes in Children and Adolescents (Chapter 34)

Type 1 diabetes remains the most common endocrine disease in childhood, with incidence rates rising globally. The 2018 Clinical Practice Guidelines stress that management in this population is uniquely complex, requiring a delicate balance between achieving strict glycemic targets to prevent long-term complications and minimizing the immediate risks of hypoglycemia and diabetic ketoacidosis (DKA).

This practice exam tests your ability to navigate these challenges, from selecting appropriate insulin regimens to managing acute complications and screening for associated autoimmune conditions.

Key Concepts Covered in This Exam:

  • Therapeutic Targets: Mastering the recommendation to aim for an A1C <7.5% across all pediatric age groups, while acknowledging that targets must be individualized based on hypoglycemia risk.

  • Insulin Regimens: Identifying basal-bolus therapy (MDI) or continuous subcutaneous insulin infusion (CSII/pumps) as the gold standard treatments for optimizing control and flexibility.

  • DKA Management: Understanding the critical protocols for treating diabetic ketoacidosis, including the cautious use of fluids and insulin to prevent cerebral edema, the leading cause of mortality in pediatric DKA.

  • Monitoring: Recognizing the need for frequent glucose monitoring (6 to 10 times daily) or the use of Continuous Glucose Monitoring (CGM) to safely manage variability.

  • Comorbidity Screening: Recalling the schedule for screening associated autoimmune diseases, specifically hypothyroidism (at diagnosis and every 2 years) and celiac disease (at diagnosis and symptomatic intervals).

1. A healthcare team is developing strategies to reduce DKA rates at diagnosis in their community. Based on evidence, what intervention is most likely to be effective?

2.

What percentage of children with type 1 diabetes have celiac disease?

3. What is the recommended A1C target for children and adolescents <18 years of age with type 1 diabetes?

4. Case: A 14-year-old female with type 1 diabetes is unable to achieve metabolic targets and insulin omission is suspected. What should be considered?

5. What is the recommended frequency of physical activity for children with type 1 diabetes?

6. Case: A 15-year-old with type 1 diabetes has symptomatic celiac disease confirmed by biopsy. What is the appropriate management?

7. At what age and diabetes duration should screening for diabetic nephropathy begin in children with type 1 diabetes?

8. What is the recommended frequency for screening children with type 1 diabetes for hypertension?

9. Case: A 13-year-old girl with type 1 diabetes has unexplained recurrent hypoglycemia and decreasing insulin requirements. What screening should be considered?

10. Case: A 7-year-old child refuses to eat due to illness and has mild hypoglycemia. The parents ask about mini-dose glucagon. What is the recommended dose?

11. Case: A clinic wants to implement strategies to reduce DKA in children with established type 1 diabetes. Based on evidence, which approach is most likely to be effective?

12. Case: A diabetes clinic is considering implementing continuous glucose monitoring (CGM) for pediatric patients. What does evidence suggest about CGM effectiveness in children?

13. Case: A 6-year-old child with type 1 diabetes has had several episodes of severe hypoglycemia. What should be considered regarding A1C targets?

14. Case: A 4-year-old child with type 1 diabetes has severe hypoglycemia and is unconscious at home. What is the appropriate dose of glucagon?

15. Case: A child in DKA has blood glucose that reaches 17.0 mmol/L during treatment. What is the most appropriate next step?

16.

Case: A clinic is developing a transition program for adolescents moving to adult care. Based on evidence, what are key components of an effective transition program?

17. At what age should screening for diabetic retinopathy begin in children with type 1 diabetes who have had diabetes for >5 years?

18. Case: A 10-year-old child with type 1 diabetes has positive thyroid peroxidase antibodies but normal TSH. What is the recommended screening frequency?

19.

Case: A 13-year-old with type 1 diabetes has depression. How might this affect diabetes management and what intervention is appropriate?

20. Case: A 2-year-old child in DKA is being treated. The child is younger than 5 years, has new-onset diabetes, severe acidosis, and significant volume depletion. Why is this child at particularly high risk?

21. Case: A 12-year-old with newly diagnosed type 1 diabetes asks about insulin pump therapy. What is an accurate statement about CSII in children?

22. Case: A 17-year-old with type 1 diabetes has a first morning urine ACR of 3.0 mg/mmol. What is the most appropriate next step?

23. A 17-year-old with type 1 diabetes has intermittent albuminuria on screening. What is the clinical significance of this finding?

24.

What percentage of children with new-onset type 1 diabetes present with diabetic ketoacidosis (DKA)?

25. Case: An 18-year-old with type 1 diabetes is preparing to transition to adult care. What percentage of young adults have no medical follow-up during the transition period?

26. Case: A 16-year-old with type 1 diabetes has an A1C persistently >10%. A comprehensive assessment should include screening for:

27. Case: A 3-year-old child in DKA is being treated. What is a critical difference in pediatric DKA management compared to adults?

28. Case: A 16-year-old female with type 1 diabetes requests contraception counselling. What is the most important reason to provide this counselling?

29. What is the preferred screening test for diabetic nephropathy in children?

30. Case: A 14-year-old with type 1 diabetes is found to have a positive tissue transglutaminase antibody but has no gastrointestinal symptoms. What action is most appropriate?

31.

Case: A 4-year-old child with newly diagnosed type 1 diabetes is medically stable. Where should initial diabetes education ideally take place?

32. Why is the relationship between severe hypoglycemia and cognitive function particularly concerning in young children with type 1 diabetes?

33. A diabetes care team is considering whether to universally screen all children with type 1 diabetes for asymptomatic celiac disease. What does current evidence suggest?

34.

Case: A 5-year-old child with type 1 diabetes has an A1C of 8.2%. The family is concerned about setting more aggressive targets. What consideration is most important in this age group?

35. At what age should routine dyslipidemia screening begin in children with type 1 diabetes who have no other risk factors?

36.

The honeymoon period in type 1 diabetes is characterized by:

37.

Case: A child in DKA is being treated. Which of the following is NOT recommended in pediatric DKA management?

38. What is the prevalence of clinical autoimmune thyroid disease in individuals with type 1 diabetes?