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CDE Diabetes

Practice Exam: Type 2 Diabetes in Children and Adolescents (Chapter 35)

The incidence of Type 2 diabetes in youth is rising at an alarming rate, presenting a distinct and aggressive clinical challenge compared to the adult-onset form. The 2018 Clinical Practice Guidelines highlight that adolescents with Type 2 diabetes face a more rapid decline in beta-cell function and a higher risk of early complications, necessitating prompt diagnosis and intensive management.

This practice exam tests your ability to identify at-risk youth, apply specific screening algorithms, and implement appropriate pharmacologic and lifestyle interventions.

Key Concepts Covered in This Exam:

  • Targeted Screening: Identifying the specific criteria for screening (e.g., age 8 with 3 risk factors or post-puberty with 2 risk factors) and the recommended interval of every 2 years.

  • Diagnostic Differentiation: Understanding how to distinguish Type 2 diabetes from Type 1 diabetes and monogenic diabetes in the pediatric population.

  • Pharmacotherapy: Identifying metformin as the first-line medication in combination with lifestyle intervention, and knowing when the addition of insulin is mandatory (e.g., severe metabolic decompensation or ketosis).

  • Comorbidity Management: Recognizing the high prevalence of associated conditions such as Polycystic Ovary Syndrome (PCOS), Nonalcoholic Fatty Liver Disease (NAFLD), and dyslipidemia.

  • Psychosocial Care: Acknowledging the critical need for mental health support, as youth with Type 2 diabetes have higher rates of depression and distress compared to their peers.

1. Case: A 15-year-old with type 2 diabetes is being started on metformin. What is the recommended titration schedule?

2. Case: A 15-year-old with type 2 diabetes reports frequent episodes of loss of control while eating unusually large amounts of food. What should be screened for?

3. Case: A 14-year-old Indigenous adolescent with obesity (BMI 97th percentile) has a mother with type 2 diabetes. How many risk factors for type 2 diabetes does this pubertal child have, and should screening be performed?

4. Case: A child with clinical type 2 diabetes has positive GAD and IA-2 antibodies. What does this suggest?

5.

Case: A 16-year-old female with type 2 diabetes asks about birth control. Why is proactive contraceptive counselling particularly important in this population?

6. What percentage of adolescents with type 2 diabetes present with obesity?

7. Case: A 13-year-old with type 2 diabetes reports snoring, morning headaches, and daytime sleepiness. What comorbidity should be screened for?

8. Case: A child with type 2 diabetes has elevated LDL-C that remains >4.1 mmol/L after 6 months of dietary intervention. The child has a family history of early cardiovascular events. What should be considered?

9.

What is the prevalence of obesity among Canadian children aged 5 to 17 years?

10. What evidence supports achieving an A1C <6.0% within the first 6 months of diagnosis in type 2 diabetes?

11. What percentage of children and youth with type 2 diabetes have a first- or second-degree relative who also has type 2 diabetes?

12. Case: A child with type 2 diabetes has been on metformin and cannot tolerate it due to gastrointestinal side effects. What alternative oral agent has been shown to be safe and effective in adolescents?

13. Case: A child is being screened for type 2 diabetes using A1C and fasting glucose. There is a discrepancy between results. What should be done?

14. What is the recommended daily duration of moderate-to-vigorous physical activity for children with type 2 diabetes?

15. Case: A 12-year-old with type 2 diabetes has persistent albuminuria confirmed over 6 months. What is the most appropriate next step?

16. What is the recommended A1C target for most children with type 2 diabetes?

17. At what frequency should children at risk be screened for type 2 diabetes?

18.

Case: A child with type 2 diabetes has elevated alanine aminotransferase (ALT). What comorbidity should be screened for?

19. How does the risk of complications in youth with type 2 diabetes compare to youth with type 1 diabetes?

20. What percentage of children with clinical type 2 diabetes are autoantibody positive, suggesting they actually have type 1 diabetes?

21.

Why is referral to a pediatric nephrologist recommended for children with type 2 diabetes and persistent albuminuria?

22.

Case: A child with type 2 diabetes on metformin for 5 months has not achieved glycemic targets. What is the next step?

23. Why should A1C not be relied upon as the sole diagnostic test to screen for type 2 diabetes in children?

24. When should screening for retinopathy begin in children with type 2 diabetes?

25. Case: A 14-year-old with type 2 diabetes presents with combined DKA and hyperglycemic hyperosmolar state (HHS). What is the expected mortality rate for this presentation?

26. Case: An 11-year-old child presents with new-onset type 2 diabetes with A1C 10.5%, polyuria, polydipsia, and weight loss. What is the most appropriate initial treatment?

27. Why is early screening and diagnosis particularly important in children at risk for type 2 diabetes?

28. Case: A 13-year-old with newly diagnosed type 2 diabetes has A1C 7.8% with minimal symptoms. What is the recommended initial pharmacological treatment?

29. Case: A pubertal female with type 2 diabetes has oligo/amenorrhea, acne, and hirsutism. What comorbidity should be considered?

30. What percentage of Canadian youth with type 2 diabetes present with diabetic ketoacidosis (DKA) at diagnosis?

31. Case: An 8-year-old nonpubertal child has obesity, acanthosis nigricans, and a parent with type 2 diabetes. How many risk factors are present, and should screening be considered?

32. What is the minimum number of risk factors required to screen for type 2 diabetes in a pubertal child?

33. What is the estimated reduction in life expectancy for individuals with early-onset type 2 diabetes?