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CDE Diabetes

Practice Exam: Type 2 Diabetes in Children and Adolescents (Chapter 35)

The incidence of Type 2 diabetes in youth is rising at an alarming rate, presenting a distinct and aggressive clinical challenge compared to the adult-onset form. The 2018 Clinical Practice Guidelines highlight that adolescents with Type 2 diabetes face a more rapid decline in beta-cell function and a higher risk of early complications, necessitating prompt diagnosis and intensive management.

This practice exam tests your ability to identify at-risk youth, apply specific screening algorithms, and implement appropriate pharmacologic and lifestyle interventions.

Key Concepts Covered in This Exam:

  • Targeted Screening: Identifying the specific criteria for screening (e.g., age 8 with 3 risk factors or post-puberty with 2 risk factors) and the recommended interval of every 2 years.

  • Diagnostic Differentiation: Understanding how to distinguish Type 2 diabetes from Type 1 diabetes and monogenic diabetes in the pediatric population.

  • Pharmacotherapy: Identifying metformin as the first-line medication in combination with lifestyle intervention, and knowing when the addition of insulin is mandatory (e.g., severe metabolic decompensation or ketosis).

  • Comorbidity Management: Recognizing the high prevalence of associated conditions such as Polycystic Ovary Syndrome (PCOS), Nonalcoholic Fatty Liver Disease (NAFLD), and dyslipidemia.

  • Psychosocial Care: Acknowledging the critical need for mental health support, as youth with Type 2 diabetes have higher rates of depression and distress compared to their peers.

1. How does the risk of complications in youth with type 2 diabetes compare to youth with type 1 diabetes?

2. At what frequency should children at risk be screened for type 2 diabetes?

3. Case: A 15-year-old with type 2 diabetes reports frequent episodes of loss of control while eating unusually large amounts of food. What should be screened for?

4.

Case: A child with type 2 diabetes on metformin for 5 months has not achieved glycemic targets. What is the next step?

5. Case: A 14-year-old Indigenous adolescent with obesity (BMI 97th percentile) has a mother with type 2 diabetes. How many risk factors for type 2 diabetes does this pubertal child have, and should screening be performed?

6. Case: A child with type 2 diabetes has elevated LDL-C that remains >4.1 mmol/L after 6 months of dietary intervention. The child has a family history of early cardiovascular events. What should be considered?

7. Case: A pubertal female with type 2 diabetes has oligo/amenorrhea, acne, and hirsutism. What comorbidity should be considered?

8. Case: A 13-year-old with type 2 diabetes reports snoring, morning headaches, and daytime sleepiness. What comorbidity should be screened for?

9.

Case: A child with type 2 diabetes has elevated alanine aminotransferase (ALT). What comorbidity should be screened for?

10. Why should A1C not be relied upon as the sole diagnostic test to screen for type 2 diabetes in children?

11.

What is the prevalence of obesity among Canadian children aged 5 to 17 years?

12. What percentage of Canadian youth with type 2 diabetes present with diabetic ketoacidosis (DKA) at diagnosis?

13. What is the recommended A1C target for most children with type 2 diabetes?

14. Case: A 12-year-old with type 2 diabetes has persistent albuminuria confirmed over 6 months. What is the most appropriate next step?

15. Case: A child is being screened for type 2 diabetes using A1C and fasting glucose. There is a discrepancy between results. What should be done?

16. Case: A 13-year-old with newly diagnosed type 2 diabetes has A1C 7.8% with minimal symptoms. What is the recommended initial pharmacological treatment?

17. What percentage of adolescents with type 2 diabetes present with obesity?

18. Case: A 15-year-old with type 2 diabetes is being started on metformin. What is the recommended titration schedule?

19.

Why is referral to a pediatric nephrologist recommended for children with type 2 diabetes and persistent albuminuria?

20. Case: An 11-year-old child presents with new-onset type 2 diabetes with A1C 10.5%, polyuria, polydipsia, and weight loss. What is the most appropriate initial treatment?

21. When should screening for retinopathy begin in children with type 2 diabetes?

22.

Case: A 16-year-old female with type 2 diabetes asks about birth control. Why is proactive contraceptive counselling particularly important in this population?

23. What percentage of children with clinical type 2 diabetes are autoantibody positive, suggesting they actually have type 1 diabetes?

24. Why is early screening and diagnosis particularly important in children at risk for type 2 diabetes?

25. What percentage of children and youth with type 2 diabetes have a first- or second-degree relative who also has type 2 diabetes?

26. What evidence supports achieving an A1C <6.0% within the first 6 months of diagnosis in type 2 diabetes?

27. What is the estimated reduction in life expectancy for individuals with early-onset type 2 diabetes?

28. What is the recommended daily duration of moderate-to-vigorous physical activity for children with type 2 diabetes?

29. Case: A child with type 2 diabetes has been on metformin and cannot tolerate it due to gastrointestinal side effects. What alternative oral agent has been shown to be safe and effective in adolescents?

30. Case: An 8-year-old nonpubertal child has obesity, acanthosis nigricans, and a parent with type 2 diabetes. How many risk factors are present, and should screening be considered?

31. Case: A child with clinical type 2 diabetes has positive GAD and IA-2 antibodies. What does this suggest?

32. Case: A 14-year-old with type 2 diabetes presents with combined DKA and hyperglycemic hyperosmolar state (HHS). What is the expected mortality rate for this presentation?

33. What is the minimum number of risk factors required to screen for type 2 diabetes in a pubertal child?